Application of 1597-32-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1597-32-6, name is 2-Amino-6-fluoropyridine, molecular formula is C5H5FN2, molecular weight is 112.11, as common compound, the synthetic route is as follows.
A mixture of 6-fluoropyridin-2-amine (0.5 g, 4.46 mmol) and 2-(methoxymethyl)pyrrolidine (0.617 g, 5.35 mmol) in water (0.2 mL) was heated to 205 C for 0.5 h in a sealed tube in a microwave oven then concentrated in vacuo. The residue was purified by chromatography (silica gel, 10 g, 200 ~ 300 mesh, ethyl acetate : petroleum ether = 1 : 15 ) to afford 6-(2- (methoxymethyl)pyrrolidin-l-yl)pyridin-2-amine (0.68 g, 74 %) as a yellow oil. LC-MS: [M + l]+ =208 ‘ tR = 1.052min.
Statistics shows that 1597-32-6 is playing an increasingly important role. we look forward to future research findings about 2-Amino-6-fluoropyridine.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu; WO2013/64445; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem