Adding a certain compound to certain chemical reactions, such as: 888327-36-4, 2-Bromo-5-(trifluoromethoxy)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H3BrF3NO, blongs to pyridine-derivatives compound. Computed Properties of C6H3BrF3NO
33.1 2-bromo-5-(trifluoromethoxy)pyridin-1-ium-1-olate Commercially available 2-bromo-5-(trifluoromethoxy)pyridine (Manchester) is dissolved in 20 mL of dichloromethane and cooled to 0 C. Trifluoroacetic acid anhydride (2.26 mL, 16.1 mmol) and hydrogen peroxide (35% solution in water, 0.941 mL, 10.7 mmol) are added and the mixture is stirred for 18 hours. The reaction mixture slowly poured into saturated aqueous sodium bicarbonate solution and extracted with dichloromethane. The combined organic phases are dried and concentrated under reduced pressure. Yield: 1.40 g (100% of theory) Mass spectrometry (ESI-): m/z=257, 259 [M+H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,888327-36-4, 2-Bromo-5-(trifluoromethoxy)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; Boehringer Ingelheim International GmbH; GODBOUT, Cedrickx; TRIESELMANN, Thomas; VINTONYAK, Viktor; (84 pag.)US2018/37594; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem