Synthetic Route of 1480-87-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1480-87-1, name is 2-Fluoro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: At room temperature, fluoro-nitro-pyridine (fluoro-nitro-benzene) (1 eq.), amino alcohol (ether, ester) (1 eq.), such as (S)-2-amino-3-(p-tolyl)propan-l-ol, and potassium carbonate (excess) are mixed in dimethylformamide. The reaction was stirred at room temperature for overnight. After filtration and removing solvent, the residue was purified by flash chromatography using 20-30% hexanes in ethyl acetate as eluent. Giving diamine compounds, such as (S)-2-((3-nitropyridin-2-yl)amino)-3-(p-tolyl)propan-l-ol, as yellow solid or oil.Reaction of 2-fluoro-3-nitro pyridine with (S)-2-amino-3-(p-tolyl)propan-l-ol yielded the product as yellow solid (50%). ‘ H NMR (400 MHz, CDCl3) d 8.44 – 8.30 (m, 3H), 7.17 (d, J = 8.0 Hz, 2H), 7.11 (d, J = 7.9 Hz, 2H), 6.66 (dd, J = 8.3, 4.5 Hz, 1H), 4.67 – 4.55 (m, 1H), 3.85 (d, J = 10.9 Hz, 1H), 3.73 (dd, J = 10.6, 6.0 Hz, 1H), 3.11 (s, 1H), 2.97 (dddd, J = 13.8, 13.8, 13.8, 7.0 Hz, 2H), 2.31 (s, 3H). 13C NMR (101 MHz, CDCl3) d 155.27, 152.67, 136.33, 135.69, 134.26, 129.36, 129.13, 128.34, 112.11, 65.38, 54.96, 37.22, 21.04.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1480-87-1, 2-Fluoro-3-nitropyridine.
Reference:
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DE BRABANDER, Jef; ROSENBAUM, Daniel; LIANG, Qiren; WANG, Wentian; (343 pag.)WO2019/191327; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem