Electric Literature of 677728-92-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 677728-92-6, name is 2-Fluoropyridine-5-carbaldehyde, molecular formula is C6H4FNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Dissolve 2-fluoro-5-formyl pyridine (5.70g, 45.6mmol) in THF (lOOmL) and cool to -78C. Slowly add via cannula, a solution of 3-butenylmagnesium bromide (lOOmL, SOmmol) over 20mm. Stir the resulting mixture at -78C for 45mm, then warm to 0C and stir for 2h, then allow mixture to warm to room temperature over lh. Slowly addsaturated aq. solution of NaHCO3 (1 OOmL) and pour the mixture into water (1 OOmL). Extract the mixture with diethyl ether (3 X lOOmL) and combine the organic solutions. Wash the organic solution with water (2 X 1 OOmL) and brine (1 OOmL), then dry over Na2504, filter and concentrate in vacuo. Purify the crude oil by flash chromatography, using a linear gradient of 100% hexanes to 80% EtOAc/hexanes as eluant, to give the titlecompound (5.16g, 62%) as a clear colorless oil. MS [EI+] 182.0 (M+H). ?H NMR(400MHz, CDC13): 8.12 (m, 1H), 7.88 (dt, 1H, J 2.5, 8.3), 7.09 (dd, 1H, J 2.8, 8.5),5.78 (m, 1H), 5.38 (d, 1H, J 4.6), 4.96 (m, 1H), 4.90 (m, 1H), 4.78 (m, 1H), 2.01 (m,2H), 1.65 (m, 2H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 677728-92-6, 2-Fluoropyridine-5-carbaldehyde.
Reference:
Patent; ELI LILLY AND COMPANY; GARDINIER, Kevin Matthew; GERNERT, Douglas Linn; HAHN, Patric James; HOLLINSHEAD, Sean Patrick; KHILEVICH, Albert; MAYHUGH, Daniel Ray; ORNSTEIN, Paul Leslie; PORTER, Warren Jaye; REEL, Jon Kevin; SCHKERYANTZ, Jeffrey Michael; SPINAZZE, Patrick Gianpietro; STEVENS, Freddie Craig; WITKIN, Jeffrey Michael; (199 pag.)WO2015/183673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem