Adding a certain compound to certain chemical reactions, such as: 52378-63-9, (3-Aminopyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 52378-63-9, blongs to pyridine-derivatives compound. SDS of cas: 52378-63-9
i. A solution sodium nitrite (2.38 g) in water (10 ml) was added dropwise to a stirred mixture of 3-amino-2-hydroxymethylpyridine (4.8 g) in aqueous hydrochloric acid (48% 10 ml) and water (5 ml) at 0-5 C. This solution of the diazonium salt was added to a hot solution of cuprous chloride (2.5 g) in conc. hydrochloric acid and following cessation of nitrogen evolution the mixture was heated on the steam bath for 0.5 hours, diluted with water and saturated with hydrogen sulphide. Filtration, concentration to low bulk and extraction with chloroform yielded 3-chloro-2-hydroxymethyl-pyridine (3.7 g), m.p. 42-44 (from n-pentane).
The synthetic route of 52378-63-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Smith Kline & French Laboratories Limited; US4024260; (1977); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem