Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 717843-51-1, name is 3-Bromo-2-methoxy-4-methylpyridine. A new synthetic method of this compound is introduced below., Product Details of 717843-51-1
Synthesis of intermediate V-d: 2-Methoxy-4-methyl-3-(4,4,5,5-tetramethyl-[l,3,2] dioxaborolan-2-yl)-pyridineA dry sealed tube under argon was charged with 3-bromo-2-methoxy-4-methylpyridine V-c (813 mg, 4.02 mmol), bis(pinacolato)diboron (1.12 g, 4.41 mmol), PdCl2(dppf :DCM (146 mg, 0.20 mmol), OAc (1.18 g, 12.0 mmol) and dry DMF (10 mL). After 1.5h at 100C, the mixture was cooled to room temperature and a further portion of catalyst (75 mg, 0.092 mmol) was added. The tube was sealed and the mixture stirred at 100C overnight. The mixture was cooled, the solvent evaporated and the mixture taken up in DCM before washing with water. The separated organics were dried (MgS0 ), filtered and evaporated before purification by column chromatography (Si02; 10% to 20%) EtOAc in cyclohexane) to afford the intermediate V-d as a mobile yellow oil (2.14g, 51%). 1H NMR (300 MHz, CDC13) delta 8.00 (d, J = 5.3 Hz, 1H), 6.65 (d, J = 5.3 Hz, 1H), 3.89 (s, 3H), 2.33 (s, 3H), 1.40 (d, J = 11.1 Hz, 12H).
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Reference:
Patent; AB SCIENCE; BENJAHAD, Abdellah; MOUSSY, Alain; CHEVENIER, Emmanuel; PICOUL, Willy; LERMET, Anne; PEZ, Didier; MARTIN, Jason; SANDRINELLI, Franck; WO2013/14170; (2013); A1;,
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