Related Products of 67058-77-9 ,Some common heterocyclic compound, 67058-77-9, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 3-nitro-1H-pyrrolo[2,3-c]pyridine (250 mg, 1.53 mmol) in DMF (5 mL) was added NaH (60% dispersion in mineral oil, 61 mg, 1.53 mmol). After stirred at 0 C for 10 mi dimethylsulfate (193 mg, 1.53 mmol) was added dropwise. After stirred at 0 C for 3 hrs, the mixture was partitioned in a mixture of ethyl acetate (50 mL) and H20 (50 mL) and the aqueous phase was extracted by ethyl acetate (50 mL x 2). Organic phase was combined, dried over anhydrous Na2SO4, and evaporated in vacuum. The residue was purified by flash column (ACN in water: 5% to 50%) to afford 1-methyl-3-nitro-1H-pyrrolo[2,3-c]pyridine (30 mg, 11%) as a white solid. ?H NIVIR (400 IVIHz, CD3OD): oe = 8.94 (d, J = 0.8 Hz, 1H), 8.61 (s, 1H), 8.43 (d, J = 5.6 Hz, 1H), 8.12 (dd, J= 5.2, 0.8 Hz, 1H), 4.06 (s, 3H). MS: m/z 178.0 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67058-77-9, 3-Nitro-1H-pyrrolo[2,3-c]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem