Application of 22245-83-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22245-83-6, name is 3-(Trifluoromethyl)pyridin-2-ol. This compound has unique chemical properties. The synthetic route is as follows.
To a mixture of 2-hydroxy-3-trifluoromethylpyridine 2a1 (39.01 g, 239 mmol) and anhydrous DMF (800 mL) under Ar is added lambda/-iodosuccinimide (4.89 g, 244 mmol) and anhydrous K2CO3 (33.72 g, 244 mmol). The mixture is allowed to stir at 600C for about 3 hours. The mixture is cooled to ambient temperature, filtered and concentrated under reduced pressure. The residue is dissolved in DCM (1 L) and the organic phase is washed with brine. The aqueous phase is adjusted to pH 4 by the addition of 2M HCI, then extracted with DCM (1 L). The combined organic extracts are washed with brine (2 L) and dried over Na2SO4. The mixture is concentrated to ~300 mL and cooled overnight in a fridge. The precipitated solid is removed by filtration and dried to provide iodide 2a2.
According to the analysis of related databases, 22245-83-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/18656; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem