Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36178-05-9, name is 3-Bromo-2-fluoropyridine. A new synthetic method of this compound is introduced below., Computed Properties of C5H3BrFN
2-fluoro-3-bromo-pyridine (1 mmol) was added to a 25 ml reaction tube.Pentamidine hydrochloride (1.2 mmol), sodium tert-butoxide (3 mmol),H2O (0.5 mL) diethylene glycol dimethyl ether (2.5 mL).The reaction was carried out at 130 ° C for a reaction time of 24 hours.Cool to room temperature.The reaction was quenched by the addition of 10 mL of ethyl acetate. The mixture was washed with 6 mL of brine, and the organic phase was separated, and the aqueous phase was extracted with ethyl acetate three times (each ethyl acetate was 6 mL). Drying, the solvent was distilled off under reduced pressure, and the organic solvent and the organic solvent were separated, and the organic solvent was separated by column chromatography to give the desired product in a yield of 89percent.
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Reference:
Patent; Wuyi University; Li Yibiao; Huang Guoling; Huang Shuo; Liao Chunshu; Zhong Zhengrong; Zhong Jingyi; (11 pag.)CN109232402; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem