If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 84539-34-4, 4-Amino-3,5-dibromopyridine.
Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84539-34-4, name is 4-Amino-3,5-dibromopyridine. A new synthetic method of this compound is introduced below., Safety of 4-Amino-3,5-dibromopyridine
3-Bromo-5-(2-fluoro-4-trifluoromethyl-phenyl)-pyridin-4-ylamine (Intermediate compound 10) To a solution of commercially available 4-amino-3,5-dibromopyridine (1.000 g, 3.9697 mmol) in DME (25 ml) and water (12 ml), 2-fluoro-4- (thfluoromethyl)phenylboronic acid (0.908 g, 4.3667 mmol) and sodium carbonate (0.841 g, 7.9394 mmol) were added. The reaction mixture was degassed and kept 5 under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichloride (0.139 g, 0.1985 mmol) was added and the resulting reaction mixture, heated at 9O0C for 2 hours, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a yellow gummy residue (~1.3 g), which eluted through silica gel with 10 15% AcOEt in hexane gave 0.520 g (-39% yield) of the pure title compound as a white solid.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 84539-34-4, 4-Amino-3,5-dibromopyridine.
Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem