Related Products of 871836-51-0 ,Some common heterocyclic compound, 871836-51-0, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 1 (1.00 g, 6.5 mmol) was suspended in acetonitrile (100 ml), and sodium nitrite (339 mg, 8.5 mmol) was added thereto and reacted in an oil bath at 50 ° C. After 1 hour, the reaction mixture was cooled to room temperature, 2-deoxy-3,5-di-O- (p-toluyl) -alpha-D-ribofuranosyl chloride (2.66 g, 6.8 mmol) And the mixture was reacted at room temperature for 30 minutes. After filtration, the filtrate was concentrated under reduced pressure, the solvent was distilled off, the residue was adsorbed on a silica gel column, washed with a mixed solution of ethyl acetate and chloroform Eluting to give compound 2 (1.77 g, 54percent).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,871836-51-0, its application will become more common.
Reference:
Patent; NIHON UNIVERSITY; SAITOU, YOSHIO; SUZUKI, AZUSA; SAITOU, MIO; (41 pag.)JP2016/138078; (2016); A;,
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