Application of 16744-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16744-81-3 as follows.
To the solution of 4-methoxypyridine-2-carbaldehyde (3.00 g, 21 mmol) in 50 ml of dichloromethane was dropwise added ethylenediamine (23 mmol, 1.6 ml) in an ice-water bath. The mixture was stirred for 1 h. Then N-bromosuccinimide (4.1 g, 23 mmol) was added at 0 °C, The mixture was slowly warmed to room temperature and stirred overnight. Washing the reaction mixture with 5percent NaOH solution (50 mL) and then saturated Na2S2O3 solution (50 mL), drying with Na2S04 and removal of the dichloromethane under vacuum directly gave the desired crude product 2-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxypyridine (3.55 g, yield 95percent), which could be used directly in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16744-81-3, its application will become more common.
Reference:
Patent; TIGER INSTRUMENTS, LLC; TANG, Weiping; ZHENG, Junrong; (23 pag.)WO2018/194537; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem