Related Products of 103058-87-3 , The common heterocyclic compound, 103058-87-3, name is 5-Bromo-2-methoxynicotinaldehyde, molecular formula is C7H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Ethylene glycol (CASNo.107-21-1, 0.51 mL, 9.2 mmol, 2.0 eq) and a spatula of p-toluenesulfonic acid (PTSA, CASNo.104-15-4) were added to a solution of 5-bromo-2-methoxynicotinaldehyde (CASNo.25016-01-7, 1.0 g, 4.6 mmol, 1.0 eq) in toluene (20 mL). The reaction mixture was heated to reflux overnight. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic phase was washed with a saturated aqueous NaHCO3 solution, dried on Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (heptane/dichloromethane 90/10 to 20/80) to give the title compound (795 mg, 83%). LC/MS (ESI+) m/z 260.2 (M+H)+.
The synthetic route of 103058-87-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Couty, Sylvain; De Lemos, Elsa; Desroy, Nicolas; Duthion, Beranger; Gfesser, Gregory A.; Greszler, Stephen N.; Housseman, Christopher Gaetan; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (263 pag.)US2018/99931; (2018); A1;,
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