In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54916-66-4, name is 5-Bromo-2-methoxynicotinic acid, the common compound, a new synthetic route is introduced below. Safety of 5-Bromo-2-methoxynicotinic acid
PREPARATION J In a 50 ml. round-bottomed reaction flask equipped with stirring bar and reflux condenser, there were placed 1.0 g. (0.0043 mole) of 5-bromo-2-methoxynicotinic acid (the product of Preparation I) and 10 ml. of methanol, followed by 50mul. of concentrated sulfuric acid. The resulting reaction mixture was then refluxed for a period of approximate 16 hours (i.e., overnight). Upon completion of this step, the mixture was cooled to room temperature (~20C.) and filtered, and the recovered precipitate was dried to constant weight to ultimately yield 695.8 mg. (66%) of pure methyl 5-bromo-2-methoxynicotinate (m.p. 90-101C.) in the form of a fluffy white solid. The pure product was further characterized by means of nuclear magnetic resonance data.
The synthetic route of 54916-66-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Goldstein Steven Wayne; Sarges Reinhard; EP306251; A2; (1989);,
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