Adding a certain compound to certain chemical reactions, such as: 65001-21-0, 5-Bromopyridine-3-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Bromopyridine-3-sulfonyl chloride, blongs to pyridine-derivatives compound. Safety of 5-Bromopyridine-3-sulfonyl chloride
To a solution of triethylamine (0.5 mL, 4 mmol) in dichloromethane (5 mL) was added 2.0 M dimethylamine in tetrahydrofuran (0.58 mL, 1.2 mmol). The resultant solution was cooled to 0 C. and 5-bromopyridine-3-sulfonyl chloride [Combi-Blocks, ST-7824] (200 mg, 0.8 mmol) in dichloromethane (1mL) was added dropwise. After stirring at 0 C. to room temperature over 1 h, the reaction mixture was concentrated via rotovap. The residue was purified by FCC to afford the title compound (0.12 g, 60%) LCMS for C7H10BrN2O2S (M+H)+: calculated m/z=265.0, 267.0; found 264.9, 266.9.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65001-21-0, 5-Bromopyridine-3-sulfonyl chloride, and friends who are interested can also refer to it.
Reference:
Patent; Incyte Corporation; Zou, Ge; Combs, Andrew P.; Buesking, Andrew W.; (62 pag.)US2016/229843; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem