Related Products of 1003-68-5 ,Some common heterocyclic compound, 1003-68-5, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Aromatic heterocyclic substrates 1s (0.1mmol), 5-methylpyridone 2b (0.15mmol), copper acetate hydrate (0.1mmol), potassium acetate (0.2mmol), DMSO (1.0mL) respectively in an air atmosphere Add to a 15mL Schlenk tube, and then directly seal the tube at 80 C for 12h. After the reaction was completed, the mixture was cooled to room temperature, and a small amount of ethyl acetate and ammonia were added to quench the reaction. The ethyl acetate was repeatedly extracted. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered under reduced pressure, and the solvent was evaporated under reduced pressure. The crude product was separated and purified by a preparative plate (DCM: MeOH = 35: 1) to obtain 3sb as a white solid, 23.2 mg, with a yield of 60%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1003-68-5, its application will become more common.
Reference:
Patent; Shanghai Laishi Blood Goods Co., Ltd.; Wang Peng; Yu Jinfeng; Li Jianjun; (32 pag.)CN110386929; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem