Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.COA of Formula: C8H17BrO.
(E)-3,4-dihydroxystyryl alkyl sulfones I [n = 0, 1, 2; R = Et, Pr, Bu, etc.], as new analogs of neurodegenerative agents, were designed and synthesized. The biol. results demonstrated that most of the target compounds preserved antioxidant and anti-inflammatory potency in scavenging reactive free radicals, protecting neuronal cells against neurotoxins such as H2O2, 6-hydroxydopamine and inhibiting lipopolysaccharide (LPS)-induced over-production of NO. Among these compounds, I [n = 2; R = cyclopentyl] exhibited prominent antioxidant activity at low concentration (2.5 μM) in H2O2 model (cell viability = 94.5%). In addition, I [n = 2; R = cyclopentyl] (IC50 = 1.6 μM) displayed better anti-inflammatory activity than that of lead compound 1 (IC50 = 13.4 μM). In view of the outstanding performance of I [n = 2; R = cyclopentyl], the apoptotic rates of H2O2-damaged PC12 cells were detected by Annexin V-FITC/PI assay. I [n = 2; R = cyclopentyl] showed higher potency in inhibition of apoptosis than 1 at low concentration (2.5 μM), consisting with the antioxidant and anti-inflammatory models. Furthermore, with the predicted CNS (+) blood-brain barrier (BBB) permeability (Pe = 6.84 x 10-6 cm s-1), low cytotoxicity and favorable physiochem. properties based on calculation, compound I [n = 2; R = cyclopentyl] can be further developed as a potential multifunctional neuroprotective agent.
Compounds in my other articles are similar to this one(8-Bromooctan-1-ol)COA of Formula: C8H17BrO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.