Related Products of 55589-47-4 ,Some common heterocyclic compound, 55589-47-4, molecular formula is C7H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step D – 4- (5-(l-(6-methoxypyrimidine-4-yI)-8-f(3-methgammalpgammaridin~2~yl) methyll-2, 4-dioxo-l, 3, 8- triazaspiroN. 51 dec-3-yI| pyridin-2-gammal) benzoic acid, (10-1) A suspension of Compound 10-C (0.9 mmol), triacetoxyborohydride (2.09 mmol) and 3- methylpyridine-2-carboxaldehyde (1.43 mmol) in dry methylene chloride was treated with acetic acid (2.85 mmol) and stirred at ambient temperature over night. The mixture was diluted with methylene chloride and water and the pH was adjusted to pH 7 with 1 N NaOH. The layers were separated and the aqueous layer washed (x2) with methylene chloride. The combined organic layers was dried (MgSClambdai) and concentrated. Reverse Phase HPLC purification (Method C) afforded the title Compound 10-D (Example 10-1) as a salt of trifluoroacetic acid; 1H NMR(DMSO): delta = 13.05 -13.43 (b, 1H), 10.15-10.29 (b, 1H), 8.85 (s, 1H), 8.79 (s, 1H), 8.53 (s, 1H), 8.26-8.29 (m, 3H), 8.08-8.12 (m, 3H), 7.76 (d, J= 7.7 Hz, 1H), 7.55 (s, 1H), 7.39-7.42 (m, 1H), 4.73 (s, 2H), 3.98 (s, 3H), 3.78 (m, 2H), 3.66 (m, 2H), 3.52-3.58 (m, 2H), 2.52 (m, 2H), 2.37 (s, 3H). LCMS (Method A): 1.58 min, m/z (MH)+ = 580.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55589-47-4, 3-Methylpicolinaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PIERCE, Joan, M.; HALE, Jeffrey, J.; MIAO, Shouwu; VACHAL, Petr; WO2010/147776; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem