With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.126325-47-1, name is 6-Bromo-2-methylpyridin-3-amine, molecular formula is C6H7BrN2, molecular weight is 187.04, as common compound, the synthetic route is as follows.Quality Control of 6-Bromo-2-methylpyridin-3-amine
Into a 50-mL seal tube was placed methyl 6-bromo-2-methylpyridin-3 -amine (500 mg, 2.67 mmol) in MeOH (15 mL) and Pd(OAc)2(120 mg, 0.53 mmol), dppf (444 mg, 0.80 mmol), TEA (809 mg, 8.01 mmol). The seal tube was evacuated and flushed three times with CO. The resulting solution was stirred for 5 h at 100C under 10 atm of CO. Then the solution was concentrated under vacuum. The residue was eluted from a silica gel column with ethyl acetate/petroleum ether (1 : 1).This resulted in 351 mg (79.2 %) of the title compound as a light yellow solid. MS-ESI: 167 (M+l).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,126325-47-1, 6-Bromo-2-methylpyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; IFM TRE, INC.; GLICK, Gary; ROUSH, William R.; VENKATRAMAN, Shankar; SHEN, Dong-Ming; GHOSH, Shomir; KATZ, Jason; SEIDEL, Hans Martin; FRANCHI, Luigi; WINKLER, David Guenther; OPIPARI JR., Anthony William; (783 pag.)WO2019/23147; (2019); A1;,
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