Adding a certain compound to certain chemical reactions, such as: 6311-35-9, 6-Bromonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H4BrNO2, blongs to pyridine-derivatives compound. Computed Properties of C6H4BrNO2
Preparation 66-Brom o-nicotinam ideTo a solution of 6-bromo-nicotinic acid (4.8g, 23.8 mmol) in dimethylsulfoxide (20ml) was added at room temperature carbonyldiimidazole (4.8g, 29.6 mmol), and the mixture stirred for 16 hours. To the mixture was added dropwise, with cooling in ice bath, 0.880 ammonia solution (40ml), then the mixture stirred for 1 hour, then poured into water (20ml). The precipitate was filtered, washed with water and dried in vacuo to give the title product as a white solid in 81% yield, 3.9g.1 HNMR(DMSO-D6, 300MHz) delta: 7.66(br.s, 1H), 7.73(d, 1H), 8.09(m, 1H), 8.15(br.s, 1H), 8.78(d, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6311-35-9, 6-Bromonicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER LIMITED; WO2007/52124; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem