Some scientific research about 6-Chloro-2-methylnicotinaldehyde

According to the analysis of related databases, 884495-36-7, the application of this compound in the production field has become more and more popular.

Application of 884495-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884495-36-7, name is 6-Chloro-2-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 6-chloro-2-methylpyridine-3-carboxaldehyde (1.87 g, 12.0 mmol), (4- hydroxy-phenylsulfanyl)-acetic acid tert-butyl ester (2.48 g, 10.7 mmol) and K2CO3 (0.830 g, EPO 6.00 mmol) in DMF (20 mL) was heated at 125 C for 1 h. The mixture was cooled to room temperature and DMF was removed. Aqueous work-up and purification by flash chromatography on basic Al2O3 gel (CH2Cl2/hexanes, 1 :1 in v/v) afforded [4-(5-formyl-6- methyl-pyridin-2-yloxy)-phenylsulfanyl]-acetic acid tert-butyi ester as a pale yellow solid (0.481 g, 13%). 1H NMR (CDCl3) delta 1.42 (s, 9H), 2.72 (s, 3H), 3.56 (s, 2H), 6.78 (d, IH, J= 8.4 Hz), 7.09-7.13 (m, 2H), 7.46-7.50 (m, 2H), 8.11 (d, IH, J= 8.4 Hz), 10.24 (s, IH).

According to the analysis of related databases, 884495-36-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
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