Electric Literature of 33252-29-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 33252-29-8 as follows.
Weigh 2.38 g of 2-chloro-6-cyanopyridine and 0.05 g of ETS-10 in a reaction tube.Add 50mL of water, heat up to 110 C reaction, TLC tracking detection,The reaction was completed in 22 hours, and after cooling, it was centrifuged.The resulting solution is distilled off to obtain a product2-chloro-6-pyridinecarboxamide 1.46 g, yield 94%,The purity is 99.75% (gas chromatography detection). Centrifuged solidRepeat the reaction, the reaction conditions, the amount of raw materials are the same as above, when repeated 4 times,The yield is above 90%, and the yield is 84% in the fifth reaction.The purity is 97% or more.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33252-29-8, its application will become more common.
Reference:
Patent; Wenzhou University; Xiong Jing; Hu Rongrong; Liu Wuqiang; Tao Yangyang; Feng Xiaogang; Zhou Zheng; (6 pag.)CN104072409; (2016); B;,
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