Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 64614-49-9, name is (6-Chloropyridin-3-yl)(morpholino)methanone. A new synthetic method of this compound is introduced below., HPLC of Formula: C10H11ClN2O2
To (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone (0.649g, 2.86mmoles) in ethanol (6mL) was added 0.270uL(3.0 equivalents) of hydrazine, followed by triethylamine 438.9uL (1.1 equivalents). The reaction was stirred overnight at 100C to give (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone. The reaction was filtered and then concentrated to dryness. The crude residue, (6-hydrazino-pyridin-3-yl)-morpholm-4-yl-methanone, weighed 0.372g(76% yield).
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Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2004/46120; (2004); A2;,
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