The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ) is researched.Computed Properties of C6H9N.Yan, Ziling; Wang, Mengya; Shi, Mengke; He, Yang; Zhang, Yi; Qiu, Shihong; Yang, Hong; Chen, Huabing; He, Hui; Guo, Zhengqing published the article 《Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy》 about this compound( cas:625-82-1 ) in Journal of Materials Chemistry B: Materials for Biology and Medicine. Keywords: BODIPY dye micelle cancer phototherapy. Let’s learn more about this compound (cas:625-82-1).
Near-IR (NIR) light-responsive nanoparticles of organic small-mol. dyes hold great promise as phototherapeutic dyes (PDs) for clin. translation due to their intrinsic merits, including well-defined structure, high purity, and good reproducibility. However, they have been explored with limited success in the development of photostable NIR PDs with extraordinary photoconversion for highly effective phototherapy. Herein, we have described amphiphilic BODIPY dye aggregates within the polymeric micelles (Micelles) as potent bifunctional PDs for dually cooperative phototherapy under NIR irradiation Micelles possessed an intensive NIR absorption, high photostability, and favorable non-radiative transition, thereby exhibiting both remarkable singlet oxygen generation and photothermal effect under NIR light irradiation Besides, Micelles had preferable cellular uptake, effective cytoplasmic drug translocation as well as enhanced tumor accumulation. Owing to the combined virtues, Micelles showed clin. potential as bifunctional PDs for photo-induced cancer therapy. This work thus provides a facile strategy to exploit advanced PDs for practical phototherapeutic applications.
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