Adding a certain compound to certain chemical reactions, such as: 626-55-1, 3-Bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 626-55-1, blongs to pyridine-derivatives compound. Recommanded Product: 626-55-1
A mixture of 264 3-bromopyridine (0.38 mL, 4.0 mmol), 265 (4-methoxyphenyl)boronic acid (500 mg, 3.3 mmol), Pd(dppf)Cl2 (69 mg, 0.094 mmol), 105 K2CO3 (720 mg, 5.2 mmol), 31 dioxane (10 mL), and 18 water (5 mL), was bubbled with N2 for 1 min and then stirred at 110 C. for 12 h. After cooling to rt, the mixture was diluted with EtOAc, filtered through Celite, the filtrate washed with water, brine, dried (MgSO4), the solvent was removed by evaporation and the residue was purified (FCC, SiO2, 0-100% EtOAc/heptanes) to provide the 266 title compound (350 mg, 57%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) delta 8.8 (d, 1H, J=2.1 Hz), 8.5 (q, 1H, J=1.2, 3.3 Hz), 7.85-7.81 (m, 1H), 7.55-7.50 (m, 2H), 7.35-7.26 (m, 1H), 7.04-6.99 (m, 2H), 3.86 (s, 1H). [M+H]=186.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,626-55-1, its application will become more common.
Reference:
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem