Reference of 6298-19-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6298-19-7, name is 2-Chloropyridin-3-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(2) Take 2-chloro-3-aminopyridine 124g, DCM 600ml,Triethylamine 111g,Add to the 2000 ml reaction flask.Take the DCM solution of the step acid chloride,Slowly drip into the reaction solution,Maintain internal temperature 15-20 C;After the completion of the dropwise addition, the reaction solution is maintained at 20-30 C for about 1 h;TLC, complete reaction to 2-chloro-3-aminopyridine;The reaction solution was poured into 800 ml of ice water.Adjust the pH to 9-11 with sodium hydroxide, stir for 30 minutes;The aqueous phase was extracted once with 300 ml of DCM; the organic phases were combined; dried over anhydrous sodium sulfate;Concentrated dryMade a pale yellow solid (2) 243g,The yield in two steps was 90.4% and the purity was 97%.
According to the analysis of related databases, 6298-19-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanjing Nuoxi Biological Technology Co., Ltd.; Zhao Xiaolin; Cui Jiayi; Liao Chaoting; Wang Jinzhu; Ai Yangbao; Zhao Bing; (7 pag.)CN109627241; (2019); A;,
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