Application of 69045-79-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 69045-79-0 as follows.
2-Chloro-5-iodopyridine (0.20 g, 0.83 mmol) was stirredfor 5h at 120C in pyridine with hydrazine hydrate (0.25mL,4.17 mmol). The solvent was removed under reduced pressureand the residue dissolved in AcOEt and extracted withwater. The organic layer was dried over Na2SO4 and concentratedto dryness to give 9a (0.19 g, 90%). IR (ATR, cm-1)3248; 3158; 2983; 1586; 1506; 1476; 1075; 805. 1H NMR(CDCl3) 8.26 (s, 1H); 7.67 (d, 1H, J= 9 Hz); 6.59 (d, 1H,J= 9 Hz). 13C NMR (CDCl3) 160.3; 153.5; 145.2; 109.3;78.5. MS (ESI+) [M+H]: 236.20. HRMS (ESI+) [M+H]+:235.9691 observed, 235.9685 calculated for C5H7IN3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69045-79-0, its application will become more common.
Reference:
Article; Joyard, Yoann; Bischoff, Laurent; Levacher, Vincent; Papamicael, Cyril; Vera, Pierre; Bohn, Pierre; Letters in Organic Chemistry; vol. 11; 3; (2014); p. 208 – 214;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem