Related Products of 6980-08-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6980-08-1, name is 4-Chloro-3-nitropyridin-2-amine, molecular formula is C5H4ClN3O2, molecular weight is 173.5572, as common compound, the synthetic route is as follows.
General procedure: To a solution of the pyridine 3 (300 mg, 1.73 mmol) [51] in absolute ethanol (10 mL) were added triethylamine (0.5 mL, 3.58 mmol) and the aniline 6 (500 mg, 1.99 mmol) [45] and the mixture was heated at reflux for 8 h. The solvent was vacuum evaporated, water was added to the residue and the precipitate was filtered, washed with water, dried and purified using silica gel column chromatography (dichloromethane) to give pure 7 (440 mg, 65%).
Statistics shows that 6980-08-1 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-3-nitropyridin-2-amine.
Reference:
Article; Gavriil, Efthymios-Spyridon; Doukatas, Aris; Karampelas, Theodoros; Myrianthopoulos, Vassilios; Dimitrakis, Spyridon; Mikros, Emmanuel; Marakos, Panagiotis; Tamvakopoulos, Constantin; Pouli, Nicole; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 393 – 409;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem