Reference of 72587-18-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 72587-18-9 as follows.
6-chloro-3- (ethanesulfonyl) pyridin-2-carboxylic acid 2.50 g, and the mixture of thionyl chloride 1.31g of toluene 30 mL, and DMF1 drop was heated under reflux for 3 hours. The reaction mixture was concentrated and dissolved in tetrahydrofuran 30 mL, under ice-cooling, 3-amino-2-chloro-5- (trifluoromethyl) pyridine 1.97 g, triethylamine 1.10g was added dropwise respectively. After stirring for 3 hours at room temperature, The reaction mixture was added to ice water, and extracted with ethyl acetate. The resulting organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography, described below 6-chloro-3- (ethanesulfonyl) – [2-chloro-5- (trifluoromethyl) pyridin-3-yl] pyridine-2-carboxamide 2.4g It was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,72587-18-9, its application will become more common.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; NAKAJIMA, YUJI; OKAWARA, YUICHI; (263 pag.)JP2016/102104; (2016); A;,
Pyridine – Wikipedia,
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