74115-13-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74115-13-2, name is 5-Bromo-3-pyridinol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-bromopyridin-3-ol (100 mg, 0.575 mmol), silver carbonate (475 mg, 1.724 mmol), and benzyl bromide (68.4 muL, 0.575 mmol) were dissolved in CHCl3 (2874 muL) and stirred for 18 hours. The reaction mixture was filtered to remove the silver salts and concentrated in vacuo. The crude material was purified by column chromatography (ISCO, 12 g silica gel column, 19 minute gradient from 0 to 100% EtOAc in hexanes) to give Intermediate 14A (41.2 mg, 0.156 mmol, 27.1%) as a yellow oil: 1H NMR (0455) (400MHz, CHLOROFORM-d) delta 8.30 (dd, J=4.4, 2.4 Hz, 2H), 7.45-7.33 (m, 6H), 5.10 (s, 2H); LC^MS: Method H, RT = 0.99 min, MS (ESI) m/z: 264/266 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis 74115-13-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; RICHTER, Jeremy M.; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; (111 pag.)WO2018/13772; (2018); A1;,
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