Electric Literature of 832735-56-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.832735-56-5, name is 4-Bromo-2-(difluoromethoxy)pyridine, molecular formula is C6H4BrF2NO, molecular weight is 224.0029, as common compound, the synthetic route is as follows.
A solution of 4-bromo-2-(difluoromethoxy)pyridine (1.25 g, 5.56 mmol) in 1,4-dioxane (30 mL) was added to Pd(dppf)Cl2(406 mg, 0.56 mmol), B2Pin2(1.55 g, 6.10 mmol) and KOAc (1.2 g, 12.2 mmol) under N2 and the reaction was heated to reflux for 22 h. The mixture was filtered through celite and concentrated in vacuo to afford the crude title compound (2.57 g) which was used without further purification.LCMS m/z 271.8 (M+H)+(ES+).1H NMR (DMSO-d6): d 8.28 (d, J = 4.9 Hz, 1H), 7.70 (t, J = 72.9 Hz, 1H), 7.41 (d, J = 4.8 Hz, 1H), 7.13 (s, 1H), 1.29 (s, 12H).
The chemical industry reduces the impact on the environment during synthesis 832735-56-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; INFLAZOME LIMITED; MILLER, David; MACLEOD, Angus; THOM, Stephen; MCPHERSON, Christopher G.; ALANINE, Thomas; CARRILLO ARREGUI, Jokin; CIANA, Claire-Lise; SHANNON, Jonathan; VAN WILTENBURG, Jimmy; DEN HARTOG, Jacobus Antonius Joseph; (603 pag.)WO2019/211463; (2019); A1;,
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