In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 896139-85-8, name is Imidazo[1,2-a]pyridin-7-ol, the common compound, a new synthetic route is introduced below. Product Details of 896139-85-8
Imidazo[1,2-a]pyridin-7-ol (3 g, 0.023 mol), 2-(2-bromo-ethoxy)tetrahydro-2H-Pyran (3.6 mL, 0.023 mol) and K2CO3 (6.32 g, 0.05 mol) were heated in DMF (100 ml) for 3 hours. The solution was cooled and evaporated to dryness. The residue was taken up with DCM+MeOH, the solution was filtered through a celite layer and the filtrate was evaporated to dryness. The residue was purified by Normal phase on E 5424(Irregular SiOH 15-40 mum 300 g MERCK). Mobile phase (0.3% NH4OH, 97% DCM, 3% MeOH), yielding 1.49 g (24.8%) of intermediate shown.
The synthetic route of 896139-85-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; US2012/41000; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem