Some scientific research about 914942-88-4

Reference of 914942-88-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 914942-88-4, name is tert-Butyl (6-amino-7-iodo-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)(methyl)carbamate. A new synthetic method of this compound is introduced below.

A1.12 (201 mg, 0.5 mmol), bis(triphenyiphosphine) palladium dichloride (21mg, 0.03 mmol), 3-bromophenylacetylene (113 mg, 0.65 mmol) copper iodide EPO W(4.3mg, 0,025 mmol) and diisopropylethylamine (0.2mL 1.5 mmol) were suspended in DMF (2.5mL) and degassed by bubbling a stream of nitrogen through the reaction for several minutes. The reaction was then heated to 75 0C for 30 minutes and was concentrated and purified by silica gel chromatography (hexane/ethylacetate gradient) to yield A75.1. (281 mg 123%) LCMS: RT = 3.47min M+H+ = 458.19. The material was used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,914942-88-4, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/122137; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem