Application of 92914-74-4, Adding some certain compound to certain chemical reactions, such as: 92914-74-4, name is Isoxazolo[5,4-b]pyridin-3-amine,molecular formula is C6H5N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92914-74-4.
Synthesis of exemplary compound 5: N-(1-(4-(Trifluoromethylthio)phenyl)-ethypisoxazolo[5,4-b]pyridin-3-amine 484 mg (2.2 mmol) of 4′-(trifluoromethylthio)acetophenone were added to a solution of 270 mg (2.0 mmol) of isoxazolo[5,4-b]pyridin-3-amine (intermediate VX001) in DCM (20 ml), and the mixture was stirred for 1 h at RT. 958 mul (6.0 mmol) of triethylsilane and 446 mul (6.0 mmol) of TFA were then added, and the reaction solution was stirred for 7 d at 60 C. After cooling to RT, the mixture was rendered basic with a sat. aq. NaHCO3 soln. The phases were separated, and the aqueous phase was again extracted with DCM. The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo. CC (EA/hexane 1:1) of the residue yielded 328 mg (1.0 mmol, 48%) of N-(1-(4-(trifluoromethylthio)phenyl)ethyl)-isoxazolo[5,4-b]pyridin-3-amine. MS: m/z 340.1 [M+H]+.
According to the analysis of related databases, 92914-74-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GRUNENTHAL GMBH; US2010/234419; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem