Safety of Ethyl nicotinate. I found the field of Chemistry very interesting. Saw the article Simultaneous enrichment and analysis of tobacco alkaloids by microextraction coupled with mass spectrometry using a poly (N-isopropyl-acrylamide-co-divinyl-benzene-co-N, N ‘-methylene diacrylamide) monolithic column published in 2019, Reprint Addresses Ding, CF (corresponding author), Ningbo Univ, Sch Mat Sci & Chem Engn, Inst Mass Spectrometry, Ningbo 315211, Zhejiang, Peoples R China.. The CAS is 614-18-6. Through research, I have a further understanding and discovery of Ethyl nicotinate.
Herein, we realized the simultaneous online detection of six tobacco alkaloids (TM) by in-tube solid-phase microextraction (In-tube SPME) coupled with mass spectrometry by a rapid, sensitive, and matrix effect-free method requiring no chromatographic separation and only minimal sample pre-treatment. A poly (N-isopropylacrylamide-co-divinylbenzene-co-N, N’-methylenediacrylamide) [Poly (NIPAAm-co-DVB-co-MBAA)] monolithic column was designed according to the chemical structures of selected TM and used as an extraction medium engaging in hydrophobic, pi-pi, and hydrogen bonding interactions with analytes, allowing them to be effectively extracted. A number of important parameters were systematically optimized to achieve maximal extraction efficiency. The ion intensity of the TM signals obtained by in-tube SPME-MS were higher than the direct MS mode by about 400 folds with the signal-to-noise ratio improved by 2-7 folds. The detection limits of the six TM were determined as 1.99-4.06 ng g(-1), with good linearity with correlation coefficients exceeding 0.99 obtained under optimal extraction conditions. Besides, TA recoveries in cigarette tobacco spiked at three concentration levels were in the range of 76.4-100.2%, and the corresponding RSDs (n = 5) were obtained as 4.32-7.16%. The extraction performance of the poly (NIPAAm-co-DVB-co-MBAA) monolithic column was well reproducible, with intra- or inter-day precision RSDs determined not to exceed 7.38%. Finally, no marked matrix effects were observed when the developed method was applied to the analysis of both high-abundance and trace level TM in practical samples, and the above technique was therefore concluded to be well suited for the detection of TAs in cigarette tobacco or other products.
Safety of Ethyl nicotinate. About Ethyl nicotinate, If you have any questions, you can contact Wu, FL; Yang, ST; Wang, L; Wei, WH; Ding, CF or concate me.
Reference:
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