Related Products of 639091-75-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.639091-75-1, name is Methyl 2-(Boc-amino)isonicotinate, molecular formula is C12H16N2O4, molecular weight is 252.27, as common compound, the synthetic route is as follows.
To a solution of C-2 (239.0 g, 0.95 mol) in THF (2400 mL) was added a solution of lithium hydroxide (45.6 g, 1.9 mol) in water (600 mL). The mixture was stirred at rt overnight, and then diluted with water (1500 mL). Most of the THF was removed under reduced pressure. The pH of the mixture was adjusted to 3 with citric acid (saturated). The precipitated product was collected and dried to give C-3 (253.0 g, crude). MS (ESI) calculated for (C11H14N2O4) [M-H] , 237.1; found, 237.0.
The chemical industry reduces the impact on the environment during synthesis 639091-75-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NURIX THERAPEUTICS, INC.; BARSANTI, Paul A.; BENCE, Neil F.; GOSLING, Jennifa; SAHA, Anjanabha; TAHERBHOY, Asad M.; ZAPF, Christoph W.; BOYLE, Kathleen; CARDOZO, Mario; MIHALIC, Jeffrey; LAWRENZ, Morgan; GALLOP, Mark; BRUFFEY, Jilliane; CUMMINS, Thomas; ROBBINS, Daniel; TANAKA, Hiroko; WANG, Chenbo; COHEN, Frederick; PALMER, Wylie; SANDS, Arthur T.; SHUNATONA, Hunter; (968 pag.)WO2019/148005; (2019); A1;,
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