Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1026796-81-5, name is N-(4-Bromopyridin-2-yl)acetamide. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of N-(4-Bromopyridin-2-yl)acetamide
To the solution of tert-butyl (4-(trimethylstannyl)phenyl)carbamate (750 mg,2.106 mmol) in DMF (7.5 mL) was added N-(4-bromopyridin-2-yl)acetamide (453mg, 2.106 mmol), K2C03 (873 mg, 6.32 mmol) and tetrabutylammonium bromide (1 .019 g, 3.16 mmol). The reaction mixture was purged with nitrogen and bis(triphenylphosphine)palladium(II) chloride (148 mg, 0.211 mmol) was added. The reaction mixture was heated at 110 C for 16 h. The reaction mixture wasdiluted with water (50 mL). The aq. layer was extracted with ethyl acetate (3 x 25 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to afford tert-butyl (4-(2-acetamidopyridin-4-yl)phenyl)carbamate (900 mg, 63% yield) as a brown sticky solid, which was used as is in the next step. LCMS (ESI) rn/c 328.2 [(M+H), calcd for C,8H22N303, 328.2]; LC/MS retentiontime (method B): tR = 1.49 min.
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; BRONSON, Joanne J.; DZIERBA, Carolyn Diane; MACOR, John E.; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; WO2015/6100; (2015); A1;,
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