Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 60832-72-6
The synthesis was carried out analogously to the reaction procedure of Example I-1 using: 0.50 g (3.67 mmol) of oxazolo[4,5-b]pyridin-2(3H)-one (cf. WO 2010/135014 A1), 0.82 g (3.67 mmol) of 2-chloro-5-chloromethyl-3-fluoropyridine (DE 102006015468 A1), 1.79 g (5.51 mmol) of cesium carbonate in 50 ml of DMF, 62.5 mg of cesium iodide. [0183] This gives 32.0 mg (3.1% of theory) of 4-(6-chloro-5-fluoropyridin-3-ylmethylloxazolo[4,5-b]pyridin-2(4H)-one. [0184] LC-MS (ESI positive): m/z found: 280.0 [M++H]. [0185] C12H7ClFN3O2 calculated: 279.0. [0186] 1H NMR (600 MHz, DMF-d6) delta 5.73 (s, 2H), 6.99 (t, 1H), 7.47 (dd, 1H), 8.08 (dd, 1H), 8.16 (dd, 1H), 7.56 (d, 1H) ppm [0187] 13C with 1H decoupling (CPD) NMR (150 MHz, DMF-d6) delta 52.4 (CH2), 112.6, 113.3, 145.2, 160.7 (hetaryl-C), 138.5 (Py-CCl), 154.9 (Py-CF), 126.4, 133.3, 146.2 (Py-C), 163.1 (C?O) ppm
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one.
Reference:
Patent; Jeschke, Peter; Schindler, Michael; Woelfel, Katharina; Ebbinghaus-Kintscher, Ulrich; Voerste, Arnd; Malsam, Olga; Losel, Peter; Goergens, Ulrich; US2014/113824; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem