Synthetic Route of 1452-63-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1452-63-7, name is Picolinohydrazide. This compound has unique chemical properties. The synthetic route is as follows.
N-picolinoyl-N0-benzothioylhydrazide (Hpbth) was prepared byadding a methanol solution of carboxymethyl dithiobenzoate(2.12 g, 10 mmol) dropwise to 1 N NaOH solution of picolinic acidhydrazide (1.37 g, 10 mmol). The reaction mixture was stirred continuouslyfor 1 h and acidified with dil. acetic acid. The precipitateobtained was filtered off, washed with water, dried under reducedpressure and recrystallized from a mixture of MeOHACHCl3 (50:50v/v) [16]. Yield: 75%; m.p. 184 C. Found: C, 60.73; H, 4.31; N,16.30; S, 12.47%. Calc. for C13H11N3SO (257.31): C, 60.70; H, 4.28;N, 16.33; S, 12.44%. IR (cm1, KBr): m(NAH) 3236; m(CO) 1661;m(NAN) 1075; m(CS) 921. 1H NMR (DMSO-d6; d ppm): 10.63,10.05 (s,2H, NH), 8.68 (C1H), 7.90 (C2H), 7.92 (C3H), 8.044 (C4H),7.65 (C9H), 7.36 (C10H), 7.34 (C11H), 7.22 (C12H), 7.50 (C13H),13C NMR (DMSO-d6; d ppm): 190.71 (CS), 163.07 (CO), 147.53(C1), 131.17 (C2), 137.53 (C3), 131.72 (C4), 149.08 (C5), 138.05(C8), 129.16 (C9, C13), 127.97 (C10, C12), 131.06 (C11).
According to the analysis of related databases, 1452-63-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kushawaha; Dani; Bharty; Chaudhari; Sharma; Kharwar; Singh; Journal of Molecular Structure; vol. 1063; 1; (2014); p. 60 – 69;,
Pyridine – Wikipedia,
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