Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929000-66-8, name is 3-Bromo-6-chloropyridine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Bromo-6-chloropyridine-2-carboxylic acid
A) methyl 3-bromo-6-chloropyridine-2-carboxylate To a solution of 3-bromo-6-chloropyridine-2-carboxylic acid (5.00 g) in methanol (90 mL) was added 98% sulfuric acid (889 mg), and the mixture was stirred at 60C for 16 hr. The reaction mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure. The obtained residue was dissolved in ethyl acetate, the solution was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (5.05 g). 1H NMR (400 MHz, DMSO-d6) delta 3.93 (3H, s), 7.70 (1H, d, J = 8.4 Hz), 8.32 (1H, d, J = 8.4 Hz).
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Reference:
Patent; Takeda Pharmaceutical Company Limited; YOGO, Takatoshi; YOSHIKAWA, Masato; SAITOH, Morihisa; KATOH, Taisuke; SEKI, Tomohiro; NAKADA, Yoshihisa; (148 pag.)EP3366684; (2018); A1;,
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