Synthetic Route of 624-28-2 ,Some common heterocyclic compound, 624-28-2, molecular formula is C5H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Under argon atmosphere,848 mL of a diethyl ether solution of 50.9 g of Compound 1 was cooled, and 131 mL of a 1.64 mol / L n-BuLi hexane solution was added dropwise at -62 C. or lower over 30 minutes.After stirring for 30 minutes at the same temperature,21.5 g of dehydrated N, N-dimethylacetamide was added dropwise over 10 minutes.Aqueous ammonium chloride solution was added and stirred at room temperature for 2 days. Extract with ethyl acetate,After drying the organic layer over anhydrous magnesium sulfate,Concentrated under reduced pressure. Without further purification,Compound 2 was used in the next reaction as it was.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Chartwell Medical Instrument Co., Ltd.; Ji, Bin; Higuchi, Masato; Suhara, Tetsuya; Chen, Chun-jen; Fujimoto, Osuke; (15 pag.)JP2019/123675; (2019); A;,
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