Application of 571189-16-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 571189-16-7, name is tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate. A new synthetic method of this compound is introduced below.
Add 100 ml of methanol, 0.10 g of 10% palladium carbon to 100 ml of the reaction vessel, and add 1.8 g of 4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester. The system is closed and nitrogen-filled to 0.3. MPa, replacement twice, pass H2 to the reactor pressure 0.3MPa, replace once, then start the reaction at room temperature, reaction 12h, HPLC analysis of the reaction solution, the raw material content is less than 0.5%. The reaction solution was filtered under reduced pressure through a 0.45 um organic filter, and then evaporated to dryness to give a white solid 1.71 g, product yield 95%, purity over 99%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,571189-16-7, tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Suzhou Laikeshide Pharmaceutical Co., Ltd.; Wang Aifeng; Liu Chuantao; Zhang Caihui; Yu Jurong; (7 pag.)CN108558745; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem