Electric Literature of 103058-87-3 , The common heterocyclic compound, 103058-87-3, name is 5-Bromo-2-methoxynicotinaldehyde, molecular formula is C7H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
n-Butyllithium (120 ml, 1.6M in hexane) is added to a suspension of 80.74 g of (3-methoxy- propyl)triphenylphosphonium bromide [11 1088-69-8] in 250 ml of tetrahydrofuran under an argon atmosphere at 0C. The reaction mixture is stirred at 0C for 50 minutes and then 28 g of 5-bromo-2-methoxypyridine-3-carbaldehyde [103058-87-3] are added. The reaction mixture is stirred at 0C for 1 hour and then at room temperature for 1 hour and diluted with tert-butyl methyl ether. The solution is washed with 1 M sodium bicarbonate solution. The organic phase is dried over sodium sulphate and evaporated. The title compound is obtained as a yellowish oil from the residue by flash chromatography (SiO2 60F). Rt = 5.03 (Gradient I)
The synthetic route of 103058-87-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2007/31558; (2007); A1;,
Pyridine – Wikipedia,
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