Synthetic Route of 145100-50-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, molecular formula is C7H4F6N2O4S2, molecular weight is 358.24, as common compound, the synthetic route is as follows.
General procedure: To a mixture of bis(3,5-bis(trifluoromethyl)phenyl)(2,5-dihydroxyphenyl)phosphineoxide (25) (291 mg, 0.500 mmol) and N-(2-pyridyl)bis(trifluoromethanesulfonimide)(358 mg, 1.00 mmol) dissolved in CH2Cl2 (5.0 mL) was added triethylamine (0.174 mL,1.25 mmol) at room temperature. After stirring for 16 h at the same temperature, to the mixture was added an aqueous saturated solution of NH4Cl (5 mL). The mixture was extracted with CH2Cl2 (10 mL × 3), and the combined organic extract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel 30 g, n-hexane/EtOAc= 8/2) to give bis(3,5-bis(trifluoromethyl)phenyl)(2,5-bis(triflyloxy)phenyl)phosphineoxide (1g) (399 mg, 0.471 mmol, 94.3%) as a colorless solid.
The chemical industry reduces the impact on the environment during synthesis 145100-50-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; Nishiyama, Yoshitake; Kamada, Shuhei; Yoshida, Suguru; Hosoya, Takamitsu; Chemistry Letters; vol. 47; 9; (2018); p. 1216 – 1219;,
Pyridine – Wikipedia,
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