The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 113118-81-3, name is 5-Bromonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H4BrNO
General procedure: To a solution of the proper bromopyridine-carbaldehyde (VI, 1 eq.) in MeOH, NaBH4 (2 eq.) was added portionwise. The mixture was stirred at room temperature for 3 hours. After this time, water was added and the mixture was concentrated under vacuum. The residue was diluted with water and extracted with DCM. The combined organic phases were dried over anhydrous MgS04, filtered and evaporated under reduced pressure to give the intermediate compound having general formula VII, which was used in the next step without further purification. (0151) (5-Bromopyridin-3-yl)methanol (Vila). The title compound was obtained according to general procedure B, step 1 using 5-bromopyridine-3-carbaldehyde (Via, 0.25 g, 1.34 mmol), NaBH4 (0.10 g, 2.69 mmol). The crude (0.15 g) was used in the next step without further purification. Yield = 60%.
With the rapid development of chemical substances, we look forward to future research findings about 113118-81-3.
Reference:
Patent; AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO – A.C.R.A.F. S.P.A.; FURLOTTI, Guido; CAVARISCHIA, Claudia; BUONFIGLIO, Rosa; OMBRATO, Rosella; IACOANGELI, Tommaso; (61 pag.)WO2019/215075; (2019); A1;,
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