Adding a certain compound to certain chemical reactions, such as: 1187830-47-2, 4,5,6,7-Tetrahydro-2H-pyrazolo[4,3-b]pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H10ClN3, blongs to pyridine-derivatives compound. Formula: C6H10ClN3
To a mixture of 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-b]pyridine (500 mg, 3.13 mmol, HCl, CAS1187830-47-2) and (Boc)2O (752 mg, 3.45 mmol) in MeOH (15 mL) was added aq.K2CO3 (3 M, 2.09 mL). The reaction mixture was stirred at 20 C. for 15 hours. On completion, the mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2) to give the title compound (500 mg, 71% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 12.05 (s, 1H), 7.55 (s, 1H), 3.66-3.55 (m, 2H), 2.65 (t, J=6.4 Hz, 2H), 1.94-1.82 (m, 2H), 1.51 (s, 9H).
The synthetic route of 1187830-47-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem