Synthetic Route of 119285-07-3, Adding some certain compound to certain chemical reactions, such as: 119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate,molecular formula is C14H22N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 119285-07-3.
To a solution of 2- (PIPERAZINE-N-T-BUTOXYCARBONYL)-5-AMINO pyridine (70 g, 0.251798 moles) dissolved in acetone (700 ml), sodium bicarbonate (42.3 g, 0.503597 moles) dissolved in water (350 ml), was added and cooled to 0 oC. BENZYLCHLOROFORMATE (85.8 g, 0.503597 moles) was added to the reaction mixture at 0 oC dropwise. After complete addition, the reaction mixture was kept at room temperature for 12 hours. Acetone was removed from the reaction mixture and diluted further with ethylacetate (2L). Washed the ethylacetate layer with water and brine solution. Dried over anhydrous sodium sulphate and concentrated to dryness. The crude compound was crystallized using ethylacetate and hexane to yield the title compound (67.4 g, yield 65 %).
According to the analysis of related databases, 119285-07-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ORCHID CHEMICALS AND PHARMACEUTICALS LTD.; WO2005/3087; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem