141-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 141-86-6, name is 2,6-Diaminopyridine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: Diamine (1mmol), alcohol (2mmol), catalyst (1mol %), KOH (50mol %) and toluene (2mL) were placed in a 25mL round bottomed flask and stirred on a preheated oil bath (100C) for 12h. Upon completion (as monitored by TLC), the reaction mixture was cooled at ambient temperature, H2O (3mL) was added and the organic layer was extracted with ethyl acetate. The organic extract was separated, dried, and concentrated. The desired product was purified by column chromatography with CH2Cl2/EtOAc as eluent.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 141-86-6, 2,6-Diaminopyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ramachandran, Rangasamy; Prakash, Govindan; Nirmala, Muthukumaran; Viswanathamurthi, Periasamy; Malecki, Jan Grzegorz; Journal of Organometallic Chemistry; vol. 791; (2015); p. 130 – 140;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem