While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14254-57-0, Isonicotinoyl chloride.
Application of 14254-57-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14254-57-0, name is Isonicotinoyl chloride, molecular formula is C6H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1Synthesis of(3-chloro-4-methoxyphenyJ)-(2-pyridin-4-ylquinolin-4-yl) amine (E 1) Step (i): Synthesis ofN-(2~acetylphenyl) isonicotinamide (1); To a mixture of orthoaminoacetophenone (2.0 grams, 14.8 mmol) and triethylamine (7.2 mL, 52.0 mmol) in dry tetrahydrofuran (15 niL) was added EPO dropwise to a freshly prepared isonicotinyl chloride (2.5 grams, 17.8 mmol) dissolved in 50 mL of tetrahydrofuran, while the mixture was stirred under a nitrogen atmosphere at 0 0C. After this mixture was stirred at 0 0C for 2 hours, the reaction mixture was allowed to warm to room temperature, and stirred overnight. The resulting mixture was poured into ice-cold water and partitioned in ethyl acetate (2 x 250 mL). The organic layers were collected and washed with water (100 mL) followed by saturated sodium chloride (125 mL) solution, dried over anhydrous sodium sulfate, and evaporated to dryness. The residue thus obtained was purified by column chromatography using ethyl acetate and petroleum ether, followed by washing with diethyl ether to afford the desired product (1) as a pink colored solid (0.975 gram); Yield: 28%.1H NMR (CDCl3, 200 MHz):delta 12.89 (br s, D2O exchangeable, NH), 8.94 (d, J = 8.4 Hz, IH), 8.83 (d, J = 5.6 Hz, 2H), 7.99 (d, J = 7.8 Hz, IH), 7.90 (d, J = 5.9 Hz, 2H), 7.65 (t, J – 8.1 Hz, IH), 7.20 (d, J = 7.6 Hz, IH), 2.74 (s, 3H). IR (KBr, cm”1): 3439.7, 1675.0, 1644.4, 1522.5, 1249.0, 757.5. MS: (CI) m/z: 241 (M++l).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14254-57-0, Isonicotinoyl chloride.
Reference:
Patent; REDDY US THERAPEUTICS, INC.; PAL, Manojit; KHANNA, Ish; SUBRAMANIAN, Venkataraman; PADAKANTI, Srinivas; PILLARISETTI, Sivaram; WO2006/58201; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem