Related Products of 15862-34-7, Adding some certain compound to certain chemical reactions, such as: 15862-34-7, name is 5-Bromo-2-hydroxy-3-nitropyridine,molecular formula is C5H3BrN2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15862-34-7.
To a round-bottom flask charged with 5-Bromo-3-nitro-pyridin-2-ol (976 mg, 4.0 mmol) was added 6.0 mL of phosphoryl chloride, the resulting suspension was heated to 105 0C and kept for 12 hrs. Then the excess POCI3 was removed under reduced pressure, the residue then was dissolved in anhydrous 10 mL of DCM, 1 mL of 3-aminopropyl-1-ol was then added. The resulting mixture was stirred for 30 min., DCM was then removed under reduced pressure to give a oil residue which was stirred at 45 0C for 12 hrs. Then the reaction was quenched with water, extracted with ethyl acetate, washed with brine and dried over sodium sulfate. After removal of solvent, the residue was obtained as a yellow solid 3-(5-bromo-3-nitro-pyridin-2-ylamino)-propan-1-ol and was used for next step without further purification. 1H NMR (400 MHz, CDCI3) delta 1.90 (2H, m), 2.60 (1 H, br.), 3.71 (2H, m), 3.78 (2H, m), 8.42 (1 H, d, J = 2.4 Hz), 8.55 (1 H, d, J = 2.4 Hz); MS m/z (MH)+: 276, 278
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15862-34-7, 5-Bromo-2-hydroxy-3-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; S*BIO PTE LTD; YU, Niefang; WO2006/101456; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem